• [contact-form-7 id=”68688″ title=”Contact form 1″]
  • (Nanowerk News) The mechanical resistance of tumors and collateral damage of standard treatments often hinder efforts to defeat cancers. However, a team of researchers from the CNRS, the French National Institute of Health and Medical Research (INSERM), Paris Descartes University, and Paris Diderot University has successfully softened malignant tumors by heating them.This method, called nanohyperthermia, makes the tumors more vulnerable to therapeutic agents. First, carbon nanotubes (CNTs) are directly injected into the tumors. Then, laser irradiation activates the nanotubes, while the surrounding healthy tissue remains intact. The team’s work was published in Theranostics (“Tumor stiffening, a key determinant of tumor progression, is reversed by nanomaterial-induced photothermal therapy”)

    Infrared images showing laser irradiation of nanotube-injected tumor in an anaesthetized mouse. The bar on the right indicates surface temperatures (°C). (Image: Iris Marangon)Researchers are increasingly turning their attention to the mechanical factors affecting tumor development. Tumors stiffen due to the abnormal organization of the collagen fibers and extracellular matrix (ECM) that hold cells from the same tissue together.In addition to being a marker of malignancy, such stiffening may help cancer cells proliferate and metastasize.Furthermore, the ECM forms a physical barrier that limits tumor penetration by therapeutic agents.

    Various treatments attempt to disrupt the structure of tumors but are double-edged swords: as ECM is common to tumors and healthy organs, degrading it does as much harm as good.Yet the team found a way around this problem for mouse tumors. After being directly injected into the tumors, CNTs were activated with near-infrared light. The laser only acts on areas of CNT concentration, heating them up.

    The researchers monitored tumor stiffness noninvasively using ultrasound shear wave elastography. This technique uses the shear or secondary wave produced by ultrasound to map tissue elasticity.In two consecutive sessions at a day’s interval, the tumors were exposed to nanohyperthermia, or localized heating to 52°C for a duration of 3 minutes. Tumors initially became more rigid before gradually softening over the 10 days or so that followed the procedure.Nanohyperthermia denatures collagen fibers locally and reduces the rigidity and volume of tumors over the long term. It disrupts the tumor microenvironment and may prove effective as an adjuvant treatment with chemotherapy.

    Read more: Nanohyperthermia softens tumors to improve treatment

     

    Comments are closed

    Sorry, but you cannot leave a comment for this post.

     

    Latest Posts

    Latest Video

     
     

    LATEST POSTS

    In less than one hour, WFNS Neuroanatomy Series Wednesday 12 pm GMT, 8 am EST

    WFNS Neuroanatomy Series Wednesday 12 pm GMT, 8 am EST TO REGISTER https://us02web.zoom.us/webinar/register/WN_tCjkjEphTrayRzDAfo5FbQ YOU TUBE LINK: https://www.youtube.com/channel/UCvMRufu7rEnrIFlbWHScE5A

    Join Mailing List

    JOIN MAILING LIST GO TO FORM AT TOP OF PAGE AND PUT YOUR EMAIL IN!! FACEBOOK

    “Neuroanatomy through Clinical Cases” , Second Edition by Hal Blumenfeld, Yale University

    SOURCE Printer Friendly Hal Blumenfeld, Yale University School of Medicine The book can be ordered through the Sinauer Associates website. Sample content is also available on that page…. Read More →

    Request a Webcast

    desertedbeach@hotmail.com

    Request Panel Spot

    desertedbeach@hotmail.com please tell us the date, time, studio of Neuroanatomist P P

    MAILING LIST

    MAILING LIST desertedbeach@hotmail.com